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Published research

Findings from research conducted using the Optum Labs Data Warehouse have been presented at national and global conferences and resulted in hundreds of publications in peer-reviewed journals. If you’re looking for a publication that isn’t listed, please email us.

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05/10/23

Kidney Function Trajectories and Health Care Costs: Identifying High-Need, High-Cost Patients

05/15/23

Development and Validation of a Prediction Model for Incident Hypothyroidism in a National Chronic Kidney Disease Cohort

11/23/23

Glucagon fill rates and cost among children and adolescents with type 1 diabetes in the United States, 2011-2021

01/28/23

Disparities in tyrosine kinase inhibitor use in older patients with gastrointestinal stromal tumors

03/16/25

Association of physical therapy care with utilization of intra-articular injections in people with knee osteoarthritis: a real-world cohort study

11/27/24

Clinician Prescribing Practices Involving Medications for Alcohol Use Disorder

03/13/23

Measurement Approaches to Estimating Methadone Continuity in Opioid Use Disorder Care

12/07/23

Risk of Severe Maternal Morbidity Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection During Pregnancy

12/23/23

Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA

01/13/24

Healthcare cost and utilization for chimeric antigen receptor (CAR) T-cell therapy in the treatment of pediatric acute lymphoblastic leukemia: A commercial insurance claims database analysis

10/22/25

The Impact of Race and Social Determinants of Health on the Invasiveness of Uterine Fibroid Treatment

04/22/24

Impact of the COVID-19 pandemic on utilization and cost for care of pediatric and young adult ALL. BMC Res Notes

11/21/24

Multidisciplinary Stakeholder Engagement in a Type 2 Diabetes Comparative Effectiveness Study Utilizing Real-world Data

08/31/23

Disparities in multimorbidity and comorbidities in rheumatoid arthritis by sex across the lifespan

10/17/25

Dose Trajectories Associated with Non-fatal Overdose among Patients Co-prescribed Opioids and Benzodiazepines: Retrospective Cohort Study

07/31/23

Cost-Effectiveness of Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Bone Marrow Transplantation: Evidence from BMT CTN 1101

02/22/24

Disparities in Acute and Chronic Complications of Diabetes Along the U.S. Rural-Urban Continuum

12/22/25

Racial and Socioeconomic Disparities in Approach to Treatment of Uterine Fibroids

12/08/24

Treatment Trends of Systemic Lupus Erythematosus from 2007 to 2023 in the USA

08/04/25

Fill Patterns of Glucose-Lowering Drugs with Cardiovascular and Kidney Benefits in the Rural and Urban United States, 2012–2021

07/25/25

Shingles vaccination in Medicare Part D and commercial enrollees after the inflation reduction act

02/01/23

Increased telehealth use and reduced severe exacerbations for asthma patients during the COVID-19 pandemic

01/23/25

GLP-1RA Use and Thyroid Cancer Risk

03/01/24

Beyond Atrial Fibrillation: Machine Learning Algorithm Predicts Stroke in Adult Patients With Congenital Heart Disease

04/01/24

Paying For AI In Healthcare: Setting The Right Precedent Amidst Growing Use

01/05/24

Daylight Saving Time Practice and the Rate of Adverse Cardiovascular Events in the United States: A Probabilistic Assessment in a Large Nationwide Study

07/07/23

Risk of herpes zoster ophthalmicus after COVID-19 vaccination in a large US healthcare claims database

07/14/23

High-deductible Health Plans and Nonfatal Opioid Overdose

10/25/24

Metabolic Bariatric Surgery in the Era of GLP-1 Receptor Agonists for Obesity Management

04/03/25

The effect of a post-bronchodilator FEV1/FVC<0.7 on COPD diagnosis and treatment: a regression discontinuity design

08/29/23

Fulfillment and Validity of the Kidney Health Evaluation Measure for People with Diabetes

01/23/24

Cost-Effectiveness of Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Older Patients With High-Risk Myelodysplastic Syndrome: Analysis of BMT CTN 1102

01/21/25

Classifying Unstructured Text in Electronic Health Records for Mental Health Prediction Models: Large Language Model Evaluation Study

01/22/25

Diabetes disparities in diabetes health care access and outcomes during the Covid-19 Pandemic in the United States

07/16/25

Predictors of Incident Benzodiazepine Co-prescription Among Patients Prescribed Long-term Opioids

09/23/24

Navigating the Realm of Claims-Based Research

01/29/25

Mortality in the families of children during the COVID-19 pandemic: evidence from a repeated cross-sectional study of children in the United States

05/08/24

Effectiveness, utilisation and cost associated with implantable loop recorders versus external monitors after ischaemic or cryptogenic stroke

06/21/23

Do High-Deductible Health Plans Incentivize Changing the Timing of Substance Use Disorder Treatment?

04/01/24

Derivation of an Annualized Claims-Based Major Adverse Cardiovascular Event Estimator in Type 2 Diabetes

04/18/25

COVID-19 impacts hospital admission rates and short- and long-term outcomes for type 1 diabetes patients

05/01/24

Epidemiology of Pediatric Ocular Surface Inflammatory Diseases in the United States Using the Optum Labs Data Warehouse

11/02/25

Development and Validation of a Mortality Prediction Model for Conservative Management (CM) vs. Dialysis in Advanced CKD: Analysis of Two National Cohorts

08/03/23

Advanced Heart Failure Characteristics and Outcomes in Commercially Insured U.S. Adults

08/17/23

Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials

09/13/24

Risk of Severe Hypoglycemia After Initiation of Noninsulin Glucose-Lowering Therapies in Adults With Type 2 Diabetes at Moderate Cardiovascular Disease Risk

05/26/23

Recombinant zoster vaccine coverage in the United States: An analysis of claims-based data

08/22/25

Invasive candidiasis following lung transplant: An Assessment of impact utilizing a national insurance claims cohort

01/08/24

Approval, Evidence, and "Off-Label" Device Utilization: The Patent Foramen Ovale Closure Story

10/02/24

Rapid multiplexed PCR (polymerase chain reaction) tests for respiratory disease improve process and time to diagnosis versus laboratory-based molecular testing.

05/16/23

Impact of high deductible health plans on U.S. adults with chronic pain

08/21/25

Invasive candidiasis following lung transplant: An Assessment of impact utilizing a national insurance claims cohort

07/31/25

Variations in the Use of Outpatient Surgery

09/19/25

Comparative Effectiveness of GLP-1 Receptor Agonists on Cardiovascular Outcomes Among Adults with Type 2 Diabetes and Moderate Cardiovascular Risk

03/03/25

Trends in obesity and glucagon-like peptide-1 receptor agonist prescriptions in type 1 diabetes in the United States. Diabetes, Obesity and Metabolism

04/07/25

Unsupervised machine learning identifies opioid taper reversal patterns in a longitudinal cohort

11/02/25

Improvements in Albuminuria Screening Among Individuals with Hypertension Associated with Electronic Health Record Clinical Decision Support Design Changes

11/03/25

Effectiveness of Elective Endovascular Intervention for Patients with Peripheral Arterial Disease and Intermittent Claudication

11/20/24

Sex Differences in the Diagnosis of Chronic Obstructive Pulmonary Disease after Spirometry

09/04/24

Telemedicine for Initiation of Alcohol Use Disorder Medications

01/17/24

Deductible imputation in administrative medical claims datasets

12/01/23

Shared Control Individuals in Health Policy Evaluations with Application to Medical Cannabis Laws

08/07/23

Spectral Clustering Identifies High-risk Opioid Tapering Trajectories Associated with Adverse Events

01/20/23

Evaluation of High-Deductible Health Plans and Acute Glycemic Complications Among Adults With Diabetes

08/02/24

Generalizability of heat-related health risk associations observed in a large healthcare claims database of patients with commercial health insurance

02/01/23

Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis

09/14/23

Use of Physical Therapy and Subsequent Falls Among Patients With Dizziness in the US

10/22/25

Racial and Socioeconomic Factors Associated with Receipt of Uterine-Preserving Treatments for Uterine Fibroids

02/13/23

Antibiotic Receipt During Outpatient Visits for COVID-19 in the US, From 2020 to 2022

01/19/23

Maternal comorbidity and adverse perinatal outcomes in survivors of adolescent and young adult cancer: A cohort study

11/27/24

Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Prescriptions in Type 2 Diabetes by Kidney and Cardiovascular Disease

03/01/25

Protective Effects of Recombinant Zoster Vaccine and Antiviral Therapy Against Cardiovascular Disease Following Herpes Zoster Infection

01/21/23

All-cause mortality after hypoglycemic and hyperglycemic emergencies among U.S. adults with diabetes

09/11/25

Comparative Risk of Adverse Pancreatic Events with GLP-1 Receptor Agonists, SGLT2 Inhibitors, DPP4 Inhibitors, and Sulfonylureas among Adults with Type 2 Diabetes at Moderate Cardiovascular Disease Risk

02/03/24

Association of platinum-based chemotherapy with live birth and infertility in female survivors of adolescent and young adult cancer

03/20/23

Cost Associated With Progression of Mildly Reduced Kidney Function Among Medicare Advantage Enrollees

03/14/24

Antibiotic Receipt for Pediatric Telemedicine Visits With Primary Care vs Direct-to-Consumer Vendors

02/15/24

Risk of Herpes Zoster Ophthalmicus Recurrence After Recombinant Zoster Vaccination

03/15/23

Validation of an administrative algorithm for transgender and gender diverse persons against self-report data in electronic health records

08/12/23

National trends in emergency conditions through the Omicron COVID-19 wave in commercial and Medicare Advantage enrollees

02/05/25

The Association of Opioid Prescriptions to Children after Discharge from Surgery and New Opioid Prescription Fills in Family Members

04/01/24

Sudden Cardiac Death or Ventricular Arrythmia in Patients Taking Levetiracetam or Oxcarbazepine

05/28/24

Moving eConsults Into Mainstream Pediatric Care

03/22/24

Enrollment in High-Deductible Health Plans and Incident Diabetes Complications

01/15/25

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

12/09/25

Identifying Invasive Mold Infections in Lung Transplant Recipients Using Claims-Based Diagnostic Codes: A Matched Cohort Analysis

10/28/25

Natural History of Crohn’s Disease and Ulcerative Colitis in Newly Diagnosed Hispanic Adults in the United States: A Population-Based Cohort Study

09/12/24

Maternal influenza vaccination and associated risk of fetal loss: A claims-based prospective cohort study

11/03/25

The time toxicity of CAR-T cell therapy for non-Hodgkin's lymphoma

02/23/23

Delayed timing of physical therapy initiation increases the risk of future opioid use in individuals with knee osteoarthritis: a real-world cohort study

05/01/24

Long-term Impact of Tropical Cyclones on Disease Exacerbation Among Children with Asthma in the Eastern United States

04/03/24

Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk

12/06/24

Long-term Outcomes of Catheter Ablation Compared with Medical Therapy in Atrial Fibrillation

01/25/24

Hospitalization, Overdose, and Mortality After Opioid Prescriptions Tied to Ophthalmic Surgery

10/24/24

Patients With Inflammatory Bowel Disease are at Increased Risk for Complications of Herpes Zoster

12/30/24

Recombinant zoster vaccine and the risk of dementia

01/27/24

Decision rules for personalized statin treatment prescriptions over multi-objectives

02/29/24

Teleophthalmology provides earlier eye care access for patients with newly-diagnosed diabetes

08/09/23

Comparative effectiveness of second line glucose lowering drug treatments using real world data: emulation of a target trial

03/19/25

Central Nervous System–Active Medication Use in Older Adults With and Without Dementia—A Retrospective Cohort Study

01/18/23

Rates of Follow-up Colonoscopy After a Positive Stool-Based Screening Test Result for Colorectal Cancer Among Health Care Organizations in the US, 2017-2020.

06/01/24

Trends in the Prescribing of Buprenorphine for Opioid Use Disorder

06/23/23

Association Between New 340B Program Participation and Commercial Insurance Spending on Outpatient Biologic Oncology Drugs

11/10/23

Personalized statin treatment plan using counterfactual approach with multi-objective optimization over benefits and risks

07/21/25

Estimated Out-of-Pocket Costs for Patients With Common Cancers and Private Insurance

02/21/24

Short term exposure to low level ambient fine particulate matter and natural cause, cardiovascular, and respiratory morbidity among US adults with health insurance: case time series study

07/24/23

Comparative Effectiveness of Anticoagulants in Patients With Cancer-Associated Thrombosis

03/24/24

Development of a Follow-Up Measure to Ensure Complete Screening for Colorectal Cancer

03/24/25

Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial

11/02/25

Oral Anticoagulant Prescribing in Atrial Fibrillation and CKD

05/01/25

Disparities in technology utilization among youth with type 1 diabetes across diverse racial and socioeconomic backgrounds

09/04/23

Choice of high-deductible health plans among enrollees with a substance use disorder

03/01/24

Racial and Ethnic Disparities in Otolaryngology Office Visit and Tympanostomy Tube Placement in Children with Otitis Media

12/26/24

Association Between Immunosuppressive Medications and COVID-19 Hospitalisation and Death: A Retrospective Cohort Study

06/19/25

Health Services Usage in Patients Receiving Buprenorphine for Opioid Use Disorder or Long-Term Opioid Therapy for Chronic Pain

11/10/23

Longitudinal trajectories of glycemic control among U.S. Adults with newly diagnosed diabetes