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Published research

Findings from research conducted using the Optum Labs Data Warehouse have been presented at national and global conferences and resulted in hundreds of publications in peer-reviewed journals. If you’re looking for a publication that isn’t listed, please email us.

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05/10/23

Kidney Function Trajectories and Health Care Costs: Identifying High-Need, High-Cost Patients

05/15/23

Development and Validation of a Prediction Model for Incident Hypothyroidism in a National Chronic Kidney Disease Cohort

10/05/22

Percutaneous Left Atrial Appendage Occlusion in Comparison to Non-Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation

01/28/23

Disparities in tyrosine kinase inhibitor use in older patients with gastrointestinal stromal tumors

09/10/22

State prescribing cap laws’ association with opioid analgesic prescribing and opioid overdose

08/05/22

Association Between State Opioid Prescribing Cap Laws and Receipt of Opioid Prescriptions Among Children and Adolescents

03/13/23

Measurement Approaches to Estimating Methadone Continuity in Opioid Use Disorder Care

11/01/22

The association of new-onset diabetes with subsequent diagnosis of pancreatic cancer—novel use of a large administrative database

04/07/22

Use of Neuroimaging for Patients With Dizziness Who Present to Outpatient Clinics vs Emergency Departments in the US

10/28/22

A cohort study examining changes in treatment patterns for alcohol use disorder among commercially insured adults in the United States during the COVID-19 pandemic

07/06/22

Association of outpatient use of renin-angiotensin-aldosterone system blockers on outcomes of acute respiratory illness during the COVID-19 pandemic: a cohort study

11/24/22

Albuminuria testing and nephrology care among insured US adults with chronic kidney disease: a missed opportunity

12/20/22

Association Between the 2021 Heat Wave in Portland, Oregon, and Seattle, Washington, and Emergency Department Visits

02/01/23

Increased telehealth use and reduced severe exacerbations for asthma patients during the COVID-19 pandemic

06/17/22

Surveillance mammography after treatment for male breast cancer

06/30/22

Anticoagulation after Bioprosthetic Aortic Valve Replacement: Are We Following the Guidelines?

11/04/22

High deductible health plans and spending among families with a substance use disorder

06/21/23

Do High-Deductible Health Plans Incentivize Changing the Timing of Substance Use Disorder Treatment?

05/26/23

Recombinant zoster vaccine coverage in the United States: An analysis of claims-based data

04/01/22

Advanced Heart Failure Characteristics and Outcomes in Privately Insured U.S. Adults

05/17/22

Association between immunosuppressive drugs and COVID-19 outcomes in patients with non-infectious uveitis in a large US claims database

05/16/23

Impact of high deductible health plans on U.S. adults with chronic pain

08/13/22

Can Observational Analyses of Routinely Collected Data Emulate Randomized Trials? Design and Feasibility of the Observational Patient Evidence for Regulatory Approval Science and Understanding Disease Project

12/15/22

Rates of Hypoglycemic and Hyperglycemic Emergencies Among U.S. Adults With Diabetes, 2011–2020

11/15/22

Drug Therapy Treatment Regimens for Transplant Ineligible Newly Diagnosed Multiple Myeloma

05/27/22

Maternal Comorbidity and Adverse Perinatal Outcomes in Female Adolescent and Young Adult Cancer Survivors: a Cohort Study

01/20/23

Evaluation of High-Deductible Health Plans and Acute Glycemic Complications Among Adults With Diabetes

02/01/23

Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis

04/11/22

Evaluation for clinical benefit of metformin in patients with idiopathic pulmonary fibrosis and type 2 diabetes mellitus: a national claims-based cohort analysis

02/13/23

Antibiotic Receipt During Outpatient Visits for COVID-19 in the US, From 2020 to 2022

01/19/23

Maternal comorbidity and adverse perinatal outcomes in survivors of adolescent and young adult cancer: A cohort study

09/12/22

Racial differences in multimorbidity and comorbidities in rheumatoid arthritis

05/01/22

The effects of patient out-of-pocket costs for insulin on medication adherence and health care utilization in patients with commercial insurance; 2007-2018

05/20/22

Teleophthalmology Using Remote Retinal Imaging During the COVID-19 Pandemic

06/15/22

Warm-season temperatures and emergency department visits among children with health insurance

01/21/23

All-cause mortality after hypoglycemic and hyperglycemic emergencies among U.S. adults with diabetes

04/27/22

Artificial Intelligence for Inflammatory Bowel Diseases (IBD); Accurately Predicting Adverse Outcomes Using Machine Learning

09/28/22

Anemia Prevalence, Type, and Associated Risks in a Cohort of 5.0 Million Insured Patients in the United States by Level of Kidney Function

03/20/23

Cost Associated With Progression of Mildly Reduced Kidney Function Among Medicare Advantage Enrollees

11/15/22

The Cost of Cellular Therapy in the Treatment of Pediatric Acute Lymphoblastic Leukemia: A Commercial Insurance Claims Database Analysis

09/29/22

Screening for idiopathic pulmonary fibrosis using comorbidity signatures in electronic health records

10/17/22

Development of a Machine Learning Algorithm based on Administrative Claims Data for Identification of ED Anaphylaxis Patient Visits

03/15/23

Validation of an administrative algorithm for transgender and gender diverse persons against self-report data in electronic health records

09/01/22

Longitudinal Cost of Septal Myectomy Versus Alcohol Septal Ablation for Hypertrophic Cardiomyopathy

09/12/22

Out-of-Pocket Cost Burden Associated With Contemporary Management of Advanced Prostate Cancer Among Commercially Insured Patients

10/12/22

Prevalence of use and characteristics of users of home-based medical care in Medicare Advantage

02/23/23

Delayed timing of physical therapy initiation increases the risk of future opioid use in individuals with knee osteoarthritis: a real-world cohort study

04/01/22

Increased Risk of Cardiovascular Hospitalization and Mortality Among Sepsis Survivors

05/31/22

Internet searches and heat-related emergency department visits in the United States

01/18/23

Rates of Follow-up Colonoscopy After a Positive Stool-Based Screening Test Result for Colorectal Cancer Among Health Care Organizations in the US, 2017-2020.

06/13/22

Long-term Risk of Overdose or Mental Health Crisis After Opioid Dose Tapering

06/23/23

Association Between New 340B Program Participation and Commercial Insurance Spending on Outpatient Biologic Oncology Drugs

10/03/22

Emulating the GRADE trial using real world data: retrospective comparative effectiveness study

07/08/22

Effects of state opioid prescribing cap laws on opioid prescribing after surgery

11/23/23

Glucagon fill rates and cost among children and adolescents with type 1 diabetes in the United States, 2011-2021

12/07/23

Risk of Severe Maternal Morbidity Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection During Pregnancy

12/23/23

Postoperative thrombotic events following major surgery in patients with a history of COVID-19: a retrospective cohort analysis of commercially insured beneficiaries in the USA

01/13/24

Healthcare cost and utilization for chimeric antigen receptor (CAR) T-cell therapy in the treatment of pediatric acute lymphoblastic leukemia: A commercial insurance claims database analysis

08/31/23

Disparities in multimorbidity and comorbidities in rheumatoid arthritis by sex across the lifespan

07/31/23

Cost-Effectiveness of Unrelated Umbilical Cord Blood Transplantation versus HLA-Haploidentical Related Bone Marrow Transplantation: Evidence from BMT CTN 1101

01/05/24

Daylight Saving Time Practice and the Rate of Adverse Cardiovascular Events in the United States: A Probabilistic Assessment in a Large Nationwide Study

07/07/23

Risk of herpes zoster ophthalmicus after COVID-19 vaccination in a large US healthcare claims database

07/14/23

High-deductible Health Plans and Nonfatal Opioid Overdose

08/29/23

Fulfillment and Validity of the Kidney Health Evaluation Measure for People with Diabetes

01/23/24

Cost-Effectiveness of Reduced-Intensity Allogeneic Hematopoietic Cell Transplantation for Older Patients With High-Risk Myelodysplastic Syndrome: Analysis of BMT CTN 1102

08/03/23

Advanced Heart Failure Characteristics and Outcomes in Commercially Insured U.S. Adults

08/17/23

Assessing the use of observational methods and real-world data to emulate ongoing randomized controlled trials

01/08/24

Approval, Evidence, and "Off-Label" Device Utilization: The Patent Foramen Ovale Closure Story

01/17/24

Deductible imputation in administrative medical claims datasets

12/01/23

Shared Control Individuals in Health Policy Evaluations with Application to Medical Cannabis Laws

08/07/23

Spectral Clustering Identifies High-risk Opioid Tapering Trajectories Associated with Adverse Events

09/14/23

Use of Physical Therapy and Subsequent Falls Among Patients With Dizziness in the US

08/12/23

National trends in emergency conditions through the Omicron COVID-19 wave in commercial and Medicare Advantage enrollees

01/25/24

Hospitalization, Overdose, and Mortality After Opioid Prescriptions Tied to Ophthalmic Surgery

01/27/24

Decision rules for personalized statin treatment prescriptions over multi-objectives

08/09/23

Comparative effectiveness of second line glucose lowering drug treatments using real world data: emulation of a target trial

11/10/23

Personalized statin treatment plan using counterfactual approach with multi-objective optimization over benefits and risks

07/24/23

Comparative Effectiveness of Anticoagulants in Patients With Cancer-Associated Thrombosis

09/04/23

Choice of high-deductible health plans among enrollees with a substance use disorder

11/10/23

Longitudinal trajectories of glycemic control among U.S. Adults with newly diagnosed diabetes

02/22/24

Disparities in Acute and Chronic Complications of Diabetes Along the U.S. Rural-Urban Continuum

03/01/24

Beyond Atrial Fibrillation: Machine Learning Algorithm Predicts Stroke in Adult Patients With Congenital Heart Disease

04/01/24

Paying For AI In Healthcare: Setting The Right Precedent Amidst Growing Use

04/01/24

Derivation of an Annualized Claims-Based Major Adverse Cardiovascular Event Estimator in Type 2 Diabetes

02/03/24

Association of platinum-based chemotherapy with live birth and infertility in female survivors of adolescent and young adult cancer

03/14/24

Antibiotic Receipt for Pediatric Telemedicine Visits With Primary Care vs Direct-to-Consumer Vendors

02/15/24

Risk of Herpes Zoster Ophthalmicus Recurrence After Recombinant Zoster Vaccination

03/22/24

Enrollment in High-Deductible Health Plans and Incident Diabetes Complications

02/29/24

Teleophthalmology provides earlier eye care access for patients with newly-diagnosed diabetes

02/21/24

Short term exposure to low level ambient fine particulate matter and natural cause, cardiovascular, and respiratory morbidity among US adults with health insurance: case time series study

03/24/24

Development of a Follow-Up Measure to Ensure Complete Screening for Colorectal Cancer

03/01/24

Racial and Ethnic Disparities in Otolaryngology Office Visit and Tympanostomy Tube Placement in Children with Otitis Media

04/22/24

Impact of the COVID-19 pandemic on utilization and cost for care of pediatric and young adult ALL. BMC Res Notes

09/23/24

Navigating the Realm of Claims-Based Research

05/08/24

Effectiveness, utilisation and cost associated with implantable loop recorders versus external monitors after ischaemic or cryptogenic stroke

05/01/24

Epidemiology of Pediatric Ocular Surface Inflammatory Diseases in the United States Using the Optum Labs Data Warehouse

09/13/24

Risk of Severe Hypoglycemia After Initiation of Noninsulin Glucose-Lowering Therapies in Adults With Type 2 Diabetes at Moderate Cardiovascular Disease Risk

09/04/24

Telemedicine for Initiation of Alcohol Use Disorder Medications

08/02/24

Generalizability of heat-related health risk associations observed in a large healthcare claims database of patients with commercial health insurance

04/01/24

Sudden Cardiac Death or Ventricular Arrythmia in Patients Taking Levetiracetam or Oxcarbazepine

05/28/24

Moving eConsults Into Mainstream Pediatric Care

09/12/24

Maternal influenza vaccination and associated risk of fetal loss: A claims-based prospective cohort study

05/01/24

Long-term Impact of Tropical Cyclones on Disease Exacerbation Among Children with Asthma in the Eastern United States

04/03/24

Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk

06/01/24

Trends in the Prescribing of Buprenorphine for Opioid Use Disorder

12/26/24

Association Between Immunosuppressive Medications and COVID-19 Hospitalisation and Death: A Retrospective Cohort Study

11/27/24

Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter 2 Inhibitor Prescriptions in Type 2 Diabetes by Kidney and Cardiovascular Disease

11/20/24

Sex Differences in the Diagnosis of Chronic Obstructive Pulmonary Disease after Spirometry

12/08/24

Treatment Trends of Systemic Lupus Erythematosus from 2007 to 2023 in the USA

11/27/24

Clinician Prescribing Practices Involving Medications for Alcohol Use Disorder

11/21/24

Multidisciplinary Stakeholder Engagement in a Type 2 Diabetes Comparative Effectiveness Study Utilizing Real-world Data

10/24/24

Patients With Inflammatory Bowel Disease are at Increased Risk for Complications of Herpes Zoster

12/06/24

Long-term Outcomes of Catheter Ablation Compared with Medical Therapy in Atrial Fibrillation

10/25/24

Metabolic Bariatric Surgery in the Era of GLP-1 Receptor Agonists for Obesity Management

12/30/24

Recombinant zoster vaccine and the risk of dementia

10/02/24

Rapid multiplexed PCR (polymerase chain reaction) tests for respiratory disease improve process and time to diagnosis versus laboratory-based molecular testing.

03/16/25

Association of physical therapy care with utilization of intra-articular injections in people with knee osteoarthritis: a real-world cohort study

03/01/25

Protective Effects of Recombinant Zoster Vaccine and Antiviral Therapy Against Cardiovascular Disease Following Herpes Zoster Infection

03/03/25

Trends in obesity and glucagon-like peptide-1 receptor agonist prescriptions in type 1 diabetes in the United States. Diabetes, Obesity and Metabolism

03/19/25

Central Nervous System–Active Medication Use in Older Adults With and Without Dementia—A Retrospective Cohort Study

03/24/25

Unintended Prolonged Opioid Use: Protocol for a Case-Controlled Trial

02/05/25

The Association of Opioid Prescriptions to Children after Discharge from Surgery and New Opioid Prescription Fills in Family Members

01/29/25

Mortality in the families of children during the COVID-19 pandemic: evidence from a repeated cross-sectional study of children in the United States

01/15/25

Trends in Osteoporosis Drug Therapy Receipt Among Commercial and Medicare Advantage Enrollees in the United States, 2011-2022

01/22/25

Diabetes disparities in diabetes health care access and outcomes during the Covid-19 Pandemic in the United States

01/23/25

GLP-1RA Use and Thyroid Cancer Risk

01/21/25

Classifying Unstructured Text in Electronic Health Records for Mental Health Prediction Models: Large Language Model Evaluation Study